Iman Ahmad Abdulati is leaving her home for the first time in 25 years for weight reduction surgery.
Iman, suffers from elephantiasis - a parasitic infection that causes extreme swelling in the limbs.
Iman will need a private plane to travel to Mumbai, India, where she is set to receive life-saving bariatric surgery.
Her doctor reckons she could lose as much as 62 stones in two years after receiving treatment.
Indian immigration officials initially denied Iman a visa, as she was unable to travel to Cairo to submit her application in person, and be fingerprinted by police. They backed down when surgeon Dr Muffazzal Lakdawala used Twitter to contact India's External Affairs Minister Sushma Swaraj to ask for help